What is the main takeaway? This article in the British Journal of General Practice examines the pharmacological factors that determine whether an N-of-1 trial can realistically be carried out in primary care. Diezi et al. identify seven key factors: onset of action, washout, titration rate, withdrawal or rebound potential, reversibility of effect, identifiability, and galenic formulation (how the medicine is made and delivered, for example tablet vs capsule or slow release).

As the demand for personalised medicine grows, there is increasing interest in methods that prioritise individual patient responses over group-level findings. Traditional clinical trials remain essential for evaluating broad treatment effects, but they often fail to capture how an intervention works for a specific patient over time. This is where N-of-1 trials come in, allowing for repeated within-person measurements to assess patterns in symptoms, behaviours, and treatment e

Physiotherapists working with complex patient presentations often face a dilemma: how to determine which intervention will yield optimal...

In recent years, the bridge between traditional medicine and naturopathy has started to strengthen. Many practitioners working in the...

Learn more about adaptive N of 1 Trials and the bayesian methods and their practical design strategies

This N of 1 trial protocol explores transpalpebral electrical stimulation as a personalised treatment for retinitis pigmentosa using single case experimental design.

This review explores how N of 1 trials and single case experimental design are used to personalise epilepsy treatment using medications, devices, and lifestyle changes.

This single case experimental design study shows how psychologically-informed physiotherapy improves neck pain by addressing illness perceptions and function.

What is the main takeaway? The study titled ‘ Deep brain stimulation for severe dystonia associated with Wilson disease: A prospective...

Learn about the historical origins of Single Case Experimental Design, right from the early foundations in 19th Century to present day.

A beginner-friendly explainer on Single Case Experimental Design, focusing on its fundamentals and applications.

Dive into the technical differences between RCTs and N of 1 Trials. Get a grasp from different POVs.

Learn about the real world application of N of 1 trials in diverse fields, backed by high quality research papers.

Read about the history and rise of N of 1 Trials right from the 1900s to the present day.

Understand how personalised medicine tailors clinical trial treatments to each patient’s unique genetics, lifestyle, and environment.

Learn the fundamentals of N-of-1 trials and how they personalise healthcare.

Discover how Single Case Experimental Designs can be used to test medical devices, analyse data, and provide personalised insights.

Explore how decentralised and remote N of 1 trials are transforming clinical research, improving patient outcomes, and tackling challenges

Read on how the FDA's Rare Disease Innovation Hub is turbocharging clinical research and therapeutic development for rare diseases.

Discover the latest insights from MTPConnect's 2024 report on Australia's thriving clinical trials sector. Learn about the sector's growth.