What is the main takeaway? This article in the British Journal of General Practice examines the pharmacological factors that determine whether an N-of-1 trial can realistically be carried out in primary care. Diezi et al. identify seven key factors: onset of action, washout, titration rate, withdrawal or rebound potential, reversibility of effect, identifiability, and galenic formulation (how the medicine is made and delivered, for example tablet vs capsule or slow release).

This N of 1 trial protocol explores transpalpebral electrical stimulation as a personalised treatment for retinitis pigmentosa using single case experimental design.

This review explores how N of 1 trials and single case experimental design are used to personalise epilepsy treatment using medications, devices, and lifestyle changes.

This single case experimental design study shows how psychologically-informed physiotherapy improves neck pain by addressing illness perceptions and function.

What is the main takeaway? The study titled ‘ Deep brain stimulation for severe dystonia associated with Wilson disease: A prospective...