Design, conduct and analyse N of 1 trials
and single case experimental designs
N-of-1 Hub is a specialist clinical trials consultancy in N of 1 trials and single case experimental designs. Led by internationally recognised experts with 50 years of combined experience, we provide methodological and operational expertise for personalised clinical research.
WHAT ARE N OF 1 TRIALS AND SINGLE CASE EXPERIMENTAL DESIGNS?
N of 1 trials and single case experimental designs (SCEDs) have the potential to revolutionise the way clinical medicine is practised and clinical research is conducted.
N of 1 trials and single case experimental designs (SCEDs) identify which treatment works best for an individual, rather than which treatment works best on average. Unlike traditional clinical trials, these methods focus on personal treatment response while still using rigorous features such as randomisation and blinding where appropriate. They are well suited to personalised care and can increase patient engagement in treatment decisions. Results from multiple N of 1 trials or SCEDs can also be combined to generate broader evidence.
N-of-1 Hub works with pharmaceutical, medtech, complementary medicine, digital health, and medicinal cannabis companies to evaluate products using N of 1 and SCED methods. We also collaborate with universities, healthcare researchers, clinicians, and CROs.
RECENT N-OF-1 HUB CLIENTS
TESTIMONIALS: HEAR WHAT OUR CLIENTS HAVE TO SAY
Bill Phillips, WaveNeuro
"N-of-1 Hub were very responsive and engaged, working with us to determine the optimal protocol using the N-of-1 design. We worked together to develop the N-of-1 protocol because it allowed us to perform a thorough, sham-controlled study without requiring a large patient population. We had a very positive experience with N-of-1 Hub. They were at all times responsive, engaged, and very thorough. We are currently evaluating additional studies in various conditions, and always look for ways to use the N-of-1 protocol design due to its ease of implementation and suitability for individualised treatments like personalized rTMS, especially if the condition is found in limited patient population sizes."
Dr Chris Oliver, Oliver Nutrition
"N-of-1 Hub was of great assistance in helping us develop our protocols for a migraine trial using a single-case design. They expertly applied knowledge to our clinical situation and were extremely professional and easy to work with. We are a firm believer that single-case designs have a very important role to play in future nutraceutical research. We highly recommend N-of-1 Hub."
Research group, University of Ottawa
"It was one of the best presentations. Well organized, at appropriate level, and with enthusiasm that makes me want to learn more. Extremely well done. Thank you so much for introducing me to such an exciting area."
Research group, University of Southern Denmark
"The workshop gave a very good overview of the SCED field, its terminology, strengths and weaknesses. There was also an opportunity to ask questions and clear up misunderstandings. The presenters were well-articulated and explained things in an understandable way with good examples. Extremely likely to recommend to others."
Dr Ali Crichton, Monash Health
"N-of-1 Hub has provided mentoring on the use of use of N-of-1 trial methodology in an Australian-first N-of-1 trial of ADHD medication in Fetal Alcohol Spectrum Disorder. N-of-1 Hub's extensive experience in trial design using N-of-1 methodologies, rich understanding of the nuance of N-of-1 trial management, and collaborative, friendly nature has facilitated high quality research and allowed us to easily overcome hurdles as they’ve arisen!"
Clinical team, University of Southern California
"N-of-1 Hub has provided our research team with timelines for all aspects to complete the project, including writing for publication. Our research will be successful, only because N-of-1 Hub rescued us when we were stuck. I would highly recommend them for any academic (or other) medical researcher interested in N-of-1 trials or single case designs or investigating rare conditions with heterogenous outcomes. No study or part of a study is too small. The services are highly flexible and available to meet your research aims and schedule, including enlightening you and your team to what you actually need"